Holders, Manchester City have been drawn away to Tottenham in the fourth round of the FA Cup, while Maidstone United – the lowest-ranked side left in the competition – travel to Championship high-flyers Ipswich.
City swept past Huddersfield 5-0 on Sunday, when Kevin De Bruyne made a return to action during the second half from a hamstring injury which had kept the Belgian out since August.
Spurs, meanwhile, had booked their place in the fourth round with a 1-0 win over Burnley on Friday night with a fine late goal from Pedro Porro.
Chelsea have also been drawn against Aston Villa in another all-Premier League meeting at Stamford Bridge. The Blues swept past Championship side Preston 4-0 on Saturday as Mauricio Pochettino’s side continued their good cup form, having also reached the semi-finals of the Carabao Cup, where they will face Middlesbrough.
Villa edged past Boro 1-0 with a late goal from Matty Cash to win a first FA Cup tie since 2016.
Manchester United, who defeated Wigan Athletic on Monday, will be away either to League Two Newport County or National League side Eastleigh.
Maidstone United, the lowest-ranked club left in the cup, visit Ipswich of the Championship. Ties will take place on the weekend of Saturday, 27 January.
Fifth-placed Spurs trail by City by one point in the Premier League table but they have beaten Pep Guardiola’s side on all five of their visits to Tottenham Hotspur Stadium.
Their meeting is one of four guaranteed all-Premier League ties, with Fulham hosting Newcastle and Brighton travelling to Sheffield United. There is the potential for a further two – West Ham will host Nottingham Forest if both win their third-round replays, while Luton will travel to Crystal Palace or Everton if they overcome Bolton.
The reward for Wolves if they win their third-round replay with fellow Premier League side Brentford is a trip to local rivals West Brom, who are chasing promotion from the Championship.
Either Bristol Rovers, 10th in League One, or Championship side Norwich will travel to Liverpool.
FA Cup fourth-round draw
Watford v Southampton
Blackburn Rovers v Wrexham
Bournemouth v Swansea City
West Brom v Brentford or Wolves
West Ham or Bristol City v Nottingham Forest or Blackpool
Leicester City v Hull City or Birmingham City
Sheffield Wednesday v Coventry City
Chelsea v Aston Villa
Ipswich Town v Maidstone United
Liverpool v Norwich City or Bristol Rovers
Tottenham Hotspur v Manchester City
Leeds United v Plymouth Argyle
Crystal Palace or Everton v Luton Town or Bolton Wanderers
Newport County or Eastleigh v Manchester United
Sheffield United v Brighton & Hove Albion
Fulham v Newcastle United